HORDB

ID: hor002092
Uniprot ID: Q9TRM8
Protein name: Relaxin B chain
Gene name: RLN
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Family: Insulin family
Source: Animal
Expression: Placenta; syncytiotrophoblast.
Disease: NA
Comments: NA
Taxonomy: Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: TDDKKLKACGRDYVRLQIEVCGSIWWGRKAGQLRE
Length: 35(26-60)
Propeptide: MLRWFLSHLLGVWLLLSQLPREIPATDDKKLKACGRDYVRLQIEVCGSIWWGRKAGQLRERRQISEPLAEVVPSSIINDPEILSLMLQSIPGMPQELRIATRSGKEKLLRELHFVLEDSNLNLEEMKKTFLNTQFEAEDKSLSKLDKHPRKKRDNYIKMSDKCCNVGCTRRELASRC
Signal peptide: MLRWFLSHLLGVWLLLSQLPREIPA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
Mechanism: NA
Cross BBB: NA
Target: RXFP2
Target Unid: Q5XM32
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002092_AF2.pdb

hor002092_ESM.pdb

Mass:	468637	Formula:	C178H289N55O51S2
Absent amino acids:	FHMNP	Common amino acids:	GKR
pI:	9.43	Basic residues:	8
Polar residues:	9	Hydrophobic residues:	11
Hydrophobicity:	-76.86	Boman Index:	-9157
Half-Life / Aliphatic Index:	7.2 hour	Aliphatic Index:	78
Instability Index:	3940	Extinction Coefficient cystines:	12615
Absorbance 280nm:	371.03